New And Precise Enalaprilat Is A Competitive Inhibitor Of The Angiotensin-Converting Enzyme (ACE)

New And Precise Enalaprilat Is A Competitive Inhibitor Of The Angiotensin-Converting Enzyme (ACE)

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACE), which cleaves the blood-pressure regulating peptide angiotensin  I. ACE has a KM = 52 μM for angiotensin  I, which is present in plasma at a concentration of 75 μM. When enalaprilat is present at 2.4 nM, the activity of ACE in plasma is 10% of its uninhibited activity. What is the value of KI for enalaprilat?

 

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