What is the monoamine theory of depression

What is the monoamine theory of depression? What evidence supports this hypothesis as a cause of affective disorder? It generally takes 2-3 weeks of chronic treatment before an antidepressant begins to have a clinical benefit, yet the drug’s pharmacological effect (for example, its inhibition of MOA, or reuptake) is immediate. What synaptic mechanisms may underlie this time lag?

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